Optimization of Guanjie Zhitonggao Patch formulation using central composite design-response surface methodology / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 86-90, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-855491
ABSTRACT
objective To develop a new Guanjie Zhitonggao Patch using hot melt pressure sensitive adhesive (HMPSA) as matrix. Methods Amounts of tackifier and plasticizer in formulation were selected as factors. Tack force, peeling strength, and release rate of drug were selected as indexes. And the central composite design-response surface methodology was applied to optimizing the formulation. Results The model obtained from this method showed a reliable predictability. The formulation in optimized region possessed some superior properties and could be used for skin application. Conclusion Formulation optimization with advantages of less trial and higher precision could be achieved using central composite design-response surface methodology because it is suitable for multielement-nonlinear regression design.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio pronóstico
Idioma:
Chino
Revista:
Chinese Traditional and Herbal Drugs
Año:
2012
Tipo del documento:
Artículo
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