Two novel polyketides from Peperomia dindygulensis / 中草药

ABSTRACT

Objective: To study the chemical constituents from Peperomia dindygulensis. Methods: The chemical constituents in chloroform fraction of ethanol extract from P. dindygulensis were isolated and purified by column chromatography over silica gel column, preparative TLC, and semi-preparative HPLC. Their chemical structures were elucidated on the basis of physicochemical and spectral data. Results: Two new polyketides were isolated from the chloroform extracting fraction of P. dindygulensis and identified as (4S)-1,4-dihydroxy-2-(1′, 13′-diketone-octadec-14′E-ene)-1-cyclohexen-3-one (1) and (4S)-1,4-dihydroxy-2-(1′,14′-diketone-octadec-12′E-ene) -1-cyclohexen-3-one (2). Conclusion: Compounds 1 and 2 are new compounds and named as peperomadinone A and peperomadinone B.