Intra-arterial thrombolysis for 576 cases of acute ischemic stroke; a single center analysis / 中国脑血管病杂志

ABSTRACT

Objective: To investigate the safety and efficacy of intra-arterial thrombolysis in the treatment of acute ischemic stroke. Methods: The clinical data of the patients in the Department of Interventional Radiology, Xuanwu Hospital, Capital Medical University from January 2000 to September 2010 were analyzed retrospectively. A total of 576 patients with acute ischemic stroke were treated with intra-arterial thrombolysis, 160 patients were female and 416 were male, their mean age was 55±10 years old. The therapeutic time windows of anterior and posterior circulation lesions were 5.1±1.8 and 9.1±2.2 h respectively, and the dosages of urokinase were 82±21 and 104±15 U respectively. Results: Circled digit one 389 patients had internal carotid arterial occlusion, their recanalization rate was 61.7%, and 68 patients were conducted with laser-assisted balloon dilation or stent placement. The improvement rate of mRS was 66.1% 2 weeks after thrombolysis, and the symptomatic intracranial hemorrhage rate was 13.3%. Circled digit two101 patients had vertebral-basilar arterial occlusion, the recanalization rate was 64.3%. Thirty patients were conducted with laser-assisted balloon dilation or stent placement. The improved rate of mRS was 43.6% 2 weeks after thrombolysis, and the symptomatic intracranial hemorrhage rate was 5.0%. Circled digit threeCerebral angiography was negative in 86 patients, accounting for 14.9% of all the cases. Conclusion: After thrombolysis of extracranial and intracranial arterial occlusion, the rate of recanalization, the improved rate of mRS, and the rate of symptomatic intracranial hemorrhage showed that arterial thrombolysis in the treatment of acute ischemic stroke is a relatively safe and effective method of treatment.