The risk factors of primary intracerebral hemorrhage: A comparison between young adults and aged over 45 / 中国脑血管病杂志

ABSTRACT

Objective: To compare the risk factors of intracerebral hemorrhage (ICH) in young adults and aged over 45. Methods: A total of 274 patients who suffered from the first attack of ICH were collected. Among them 34 were attributed to young adults group, and 240 were aged over 45 group. The incidence of various risk factors were calculated, the differences of risk factors, and the influence of the exposure of various risk factors between these two groups were compared. Results: Hypertension was the most prominent risk factor in patients with ICH in this study, and its incidence was 70.1%, the incidence in the young adult group and the aged over 45 group were 55.9% and 72.0% respectively, but there was no significant difference. Then the subsequent orders were hyperhomocysteinemia, history of ischemic stroke, cigarette smoking and alcoholic consumption. The incidence of history of ischemic stroke in the young adult group was 11.8%, and the aged over 45 group was 31.3%, and there was significant difference between these two groups (P > 0.05). There were no significant differences on hyperhomocysteinemia cigarette smoking and alcoholic consumption in both groups. The patients with the suspected inducing factors before the symptom onset in the young adult group and the aged over 45 group were 50.0% and 24.6% (P < 0.01) respectively. The patients with the inducing factors of fatigue or emotional agitation in both groups were 41.2% and 13.8% (P < 0.01) respectively. The symptom onset of the patients during the active state in both groups were 76.5% and 52.9% (P < 0.05) respectively. The risk factors that closely correlated with the onset of ICH were fatigue and emotional agitation before the hemorrhage in the young adult group (OR 4.370, 95% CI 2.012-9. 490, P < 0.01). Conclusion: History of hypertension is the common risk factors of ICH in the young adults and the aged over 45. Patients with history of ischemic stroke in the aged over 45 group is higher than that in the young adult group. Fatigue or emotional agitation before the symptom onset in the young adult group is higher than the aged over 45 group.