Expression of vascular endothelial growth factor in vascular malformations of spinal cord / 中国脑血管病杂志

ABSTRACT

Objective: To observe the expression of VEGF in the spinal vascular malformations by immunohistochemical staining. This study will provide useful information for better understanding of the etiology and development of the spinal vascular malformations. Methods: The specimens (including 31 AVMS, 17 CMs) were collected as the experimental group. Ten specimens of normal spinal cord were obtained from autopsy served as the control group. VEGF expression were performed by immunohistochemistry and all the stained sections were observed under light microscope recording the positive site. SPSS 11.0 statistical software were used to analyze the relationship between VEGF and some clinical features. Results: All 58 lesions were stained positive for VEGF, with the SCAVMs staining somewhat more intensely (P < 0.01) and the control group are almost negative staining. Bleeding and pre-embolization can lead to the raising of expression of VEGF. To the SCAVM group, the expression of VEGF on inner membrane and tunica media stains more intensely than ectal membrane. And the artery showed more positive staining than vein. Conclusion: VEGF maybe play an important role in the etiology and development of spinal vascular malformations. Haemorrhagia and embolism influence the express of VEGF in vascular malformations of spinal cord.