Role and progress of innate immunity in pathogenesis of osteoarthritis / 中国修复重建外科杂志
Chinese Journal of Reparative and Reconstructive Surgery
;
(12): 370-376, 2019.
Artículo
en Chino
| WPRIM
| ID: wpr-856597
ABSTRACT
Objective:
To review and summarize the role and progress of innate immunity in the pathogenesis of osteoarthritis (OA).Methods:
The domestic and foreign literature in recent years was reviewed. The role of innate immune-mediated inflammation, macrophages, T cells, and complement systems in the pathogenesis of OA, potential therapeutic targets, and the latest research progress were summarized.Results:
With the deepening of research, OA is gradually considered as a low-grade inflammation, in which innate immunity plays an important role. The polarization of synovial macrophage subpopulation in OA has been studied extensively. Current data shows that the failure of transformation from M1 subtype to M2 subtype is a key link in the progression of OA. T cells and complement system are also involved in the pathological process of OA.Conclusion:
At present, the role of innate immunity in the progress of OA has been played in the spotlight, whereas the specific mechanism has not been clear. The macrophage subtype polarization is a potential therapeutic target for early prevention and treatment of OA.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio de etiología
Idioma:
Chino
Revista:
Chinese Journal of Reparative and Reconstructive Surgery
Año:
2019
Tipo del documento:
Artículo
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