Serum transferrin as a liver fibrosis biomarker in patients with chronic hepatitis B
Clinical and Molecular Hepatology
;
: 347-354, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-85685
ABSTRACT
BACKGROUND/AIMS:
Transferrin and alpha-1 antitrypsin are reportedly associated with liver fibrosis. We evaluated the usefulness of serum transferrin and alpha-1 antitrypsin as new liver fibrosis markers in patients with chronic hepatitis B.METHODS:
The study included 293 patients with chronic hepatitis B who underwent a liver biopsy between October 2005 and June 2009, and who had no history of hepatocellular carcinoma. Serum markers and liver fibrosis stages were compared.RESULTS:
Univariate analysis revealed that age (P<0.001), serum platelet count (P<0.001), and serum alkaline phosphatase level (P=0.003) differed significantly between the patients with and without liver cirrhosis. Serum transferrin levels were significantly lower in advanced fibrosis than in mild fibrosis in both univariate analysis (P=0.002) and multivariate analysis (P=0.009). In addition, the serum transferrin level was significantly lower in cirrhotic patients than in noncirrhotic patients (P=0.020). However, the serum level of alpha-1 antitrypsin was not significantly associated with liver cirrhosis in patients with chronic hepatitis B.CONCLUSIONS:
Serum transferrin could be promising serum marker for predicting advanced liver fibrosis in patients with chronic hepatitis B.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Biomarcadores
/
Alfa 1-Antitripsina
/
Análisis Multivariante
/
Estudios Retrospectivos
/
Curva ROC
/
Área Bajo la Curva
/
Hepatitis B Crónica
/
Transferrinas
/
Cirrosis Hepática
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Adolescente
/
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Clinical and Molecular Hepatology
Año:
2014
Tipo del documento:
Artículo
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