Research progress of hepatocellular carcioma patient-derived human tumor xenograft models / 中国药理学通报

ABSTRACT

Patient-derived human tumor xenograft (PDX) models can maintain the histopathological, growth and metastasis characteristics of primary tumors well, and can still retain these characteristics of primary tumors in large degreeafter multiple passages. It is closely related to the tumors of primary patients with great importance in scientific research. The hepatocellular carcinoma PDX models has been used in patients'individualized drug screening, evaluation of drug efficacy, exploration of treatment direction, occurrence and development mechanism of hepatocellular carcinoma, etc. It shows excellent application prospects. This article reviews the methods, applications and tumorigenie factors of hepatocellular carcinoma PDX model.