Perineuronal nets-a double-edged sword regulating neuropsychiatric disorders / 中国药理学通报

ABSTRACT

Perineuronal nets (PNNs) are unique extracellular matrix (ECM) structures surrounding parvalbumin (PV) positive intemeurons in the central nervous system (CNS). The intact structure of PNNs is critical to the function of CNS. PNNs regulate the function of GABA neurons, inhibit the damage of neurons induced by reactive oxygen species, and also participate in the regulation of neuroplasticity and the development of central nervous system. They will change in quantity and quality after mental disorders, aging, memory and drug abuse. Here the focus is on how the PNNs protect interneuron and control plasticity , and on the role of PNNs in memory in normal aging, Alzheimer's disease and drug addiction, and the association with altered PNNs formation. Understanding the molecular mechanism on PNNs would offer insights into new treatments of relevant diseases.