Effects of curcumol on contraction of jejunum and ileum smooth muscles in rats / 中国药理学通报

ABSTRACT

Aim To investigate the effects of curcumol on the contractile activity of isolated jejunum and ileum smooth muscles in rats and explore its underlying mechanism. Methods Jejunum and ileum specimens were randomly divided into five groups (n = 12) curcumol group, atropine plus curcumol group, isoprena- line plus curcumol group, norepinephrine plus curcumol group, Ca2t and curcumol group. The contractile amplitude and tension of jejunum and ileum were recorded by constant temperature perfusion. Results Curcumol promoted the contraction of normal intestinal smooth muscles and antagonize the effects of atropine, norepinephrine, isoprenaline and verapamil on relaxation of intestinal smooth muscles. Conclusions Curcumol can significantly promote the contraction of isolated jejunum and ileum smooth muscles, which may be achieved through M receptor, a receptor, p receptor and promoting extracellular calcium influx.