Research progress of small molecule activators in Keapl -Nrf2 -ARE signaling pathway / 中国药理学通报

ABSTRACT

Keapl-Nrf2-ARE pathway represents one of the most important cellular defense mechanisms against oxidative stress. The expression of various detoxifying, antioxidant defense enzymes and proteins depend on the activation of the Nr£2 signaling. Keapl-Nrf2-ARE signaling pathway has become an attractive target for the prevention and treatment of oxidative stress-related diseases including neurodegenerative, cancer, cardiovascular, metabolic and inflammatory diseases. Activating Nrf2 signaling pathway can prevent and treat various oxidative stress-induced diseases. Therefore, discovering and studying the activators of Nrf2 has received extensive attention from researchers. In this paper, we have summarized the mechanism of the Keapl-Nrf2-ARE pathway and the research progress of some small molecule activators in this pathway.