Advances of role of Epac in fibrotic diseases / 中国药理学通报

ABSTRACT

Epac, an exchange protein directly activated by cAMP, is a newly discovered guanine nucleotide exchange factor. Epac is a key factor involved in a series of cAMP mediated signaling pathways. Fibrosis disease, a common disease in clinic, usually results from excessive deposition of extracellular matrix under the stimulation of normal physiology (such as aging) or different pathogenetic factors. Epac has been reported to play an important role in fibrotic diseases, so this paper reviews this role of Epac in order to promote the research and development of Epac related mechanisms and drugs.