Role of gap junction protein connexin43 in pathogenesis of neuro-disorders / 中国药理学通报

ABSTRACT

Gap junction (GJ), which mainly consists of connexins, is a linking method between neighboring cells. Neighboring cells exchange substances, energy and information by gap junction intercellular communication mediated by GJ. Particularly, Cx43 protein is one of the most important members of Cx family. The study in recent years demonstrated the features of Cx43 protein and its important roles in the pathogenesis of neurological disorders, tumors, cardiovascular risks. This article summarizes the structure, functions, coding gene, structure analysis, synthesis, membrane localization, regulation of Cx43. Furthermore, this article explains the physiological functions of Cx43 in human bodies and its important roles in the pathogenesis of related neurological disorders.