Interactions between angiotensin converting enzyme inhibitors and aspirin / 中国药理学通报

ABSTRACT

Both aspirin and angiotensin converting enzyme (ACE) inhibitors are often used concomitantly in patients with cardiovascular disease. The safety of the combination has been questioned. The potential antagonistic interactions between ACE inhibitors and aspirin has become the focus of both increasing research and intense debate, with conflicting conclusions having been reported in the literature. We reviewed systematically available literature on the interactions between ACE inhibitors and aspirin in hypertension, acute myocardial infarction and congestive heart failure and found that further trials are needed to shed light on the effects and mechanism of interaction between these drugs.