Protective effects of total saponins of tribulus on cerebral ischemia reperfusion injury in rats / 中国药理学通报

ABSTRACT

Aim: To observe the protective effects of total saponins of tribulus (TST) on cerebral ischemia reperfusion injury in rats. Methods: Rat cerebral ischemia-reperfusion injury was induced by middle cerebral artery occlusion . The neurological outcome was evaluated. CK, LDH and NO activity in serum, SOD and MDA levels of cerebral tissue were measured. Results: The levels of CK, LDH, NO, SOD and MDA in TST(30 mg·kg-1, 10 mg·kg -1) groups were significantly lower than those in model group. The level of cellular and intercellular edema was reduced markly in the pathomorphology examination. The neurological deficits was decreased by TST. Conclusion: TST has protective effects on cerebral ischemia reperfusion injury in rats.