Effect of dauricine on platelet aggregation of patients with acute myocardial infarction / 中国药理学通报

ABSTRACT

AIM: To investigate the possibility of dauricine (DAU) to inhibit the irreversible platelet aggregation of patients with acute myocardial infarction (AMI). METHODS: Glycoprotein IV (GP IV) and thrombospondin(TSP) levels on the membrane surface of the stationary platelet or platelet activated by thrombin(50,100, 500, 1 000 U·L-1) in 12 patients with AMI were measured with a washed platelet flowcytometric assay and compared with those of the healthy (n = 14). RESULTS: The GP IV, TSP level of stationary platelet and activated platelet in patients with AMI were higher than those in the healthy significantly (P<0.05, 0.01), DAU (50 μmol·L-1) inhibited the GPIV membrane redistribution and the release of TSP from intracellular αgranules induced by thrombin (50 U·L-1, 100 U·L-1, 500 U·L-1) apparently (P<0.05, 0.01), inhibitory effect of DAU was not found in platelets activated with high concentraction of thrombin (1 000 U·L-1). CONCLUSION: The activity and reactivity to thrombin of platelets increased in patients with AMI and DAU may have a blocking effect on the consolidation of platelet aggregation in AMI.