Effects of Bombina maxima protein on growth of bladder cancer cell lines and expession of telomerase / 中国药理学通报

ABSTRACT

AIM: To study the boosting effect of Bombina maxima protein on bladder cancer cell lines growth and expression of telomerase. METHODS: Cell culture was used to dectect the effects of 3 blad der cancer cell lines growth; TRAP-PCR-ELISA method was used to detect the telomerase express under the ID50 culture concentration. RESULTS: Bombina maxima protein had the strong effect on growth of cell lines; particularly in the first 48 h; no effect was found in telomerase expression. CONCLUSION: Bombina maxima protein has the direct inhibitory effect on bladder cancer cell lines growth; The mechanism of antitumor of Bombina maxima protein is not by telomerase.