The inhibitory effect of tamoxifen on the proliferation of the anterior pituitary cell of rats / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12): 187-189, 2002.
Artículo
en Chino
| WPRIM
| ID: wpr-857459
ABSTRACT
AIM:
To investigate the effect of tamoxifen on the proliferation of the anterior pituitary cell of rats and its mechanism.METHODS:
Primary culture of the anterior pituitary cell of rats and 3HTdR incorporation method were applied. The changes of cell morphology were observed directly by electric microscope.RESULTS:
Tamoxifen could inhibit the proliferation of the anterior pituitary cell of rats. The inhibitory effect of tamoxifen (0.1 μmol·L-1) could be reversed by estrogen. The classical apoptotic changes appeared in the cells after tamoxifen incubation for 48 h.CONCLUSION:
Tamoxifen can inhibit the proliferation of the anterior pituitary cell of rats and resultin the cell apoptosis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Pharmacological Bulletin
Año:
2002
Tipo del documento:
Artículo
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