Research progress in relationships between intestinal flora imbalance and gastrointestinal motility disorders in neurodegenerative diseases / 中国药理学与毒理学杂志

ABSTRACT

Alzheimer disease, Parkinson disease, and multiple sclerosis are common neurodegenerative diseases, which are often accompanied by gastrointestinal motility disorders and intestinal flora imbalance. Gut microbiota have been shown to regulate brain function through the neuroendocrine system and the nervous immune system. It has been found that gastrointestinal dysfunction occurs earlier than neurodegenerative disease, and that gut microbiota are closely related to gastrointestinal motility. Intestinal flora may also affect neurodegenerative diseases through intestinal nerve systems. This article aims to review the recent advances in the study of the mechanism by which gut microbiota regulate neurodegenerative diseases with gastrointestinal motility disorders through crosstalk of the neuroendocrine system and the nervous immune system in order to facilitate the future study of the pathophysiology of neurodegenerative diseases as well as the treatment of neurodegenerative diseases from gastroin-testine.