Research advances in interaction between il-4 and il-13, and m2 alveolar macrophages in pulmonary fibrosis / 中国药理学与毒理学杂志

ABSTRACT

Type-2 helper T cells (Th2) are a group of cells differentiated from CD4∗ T cells after antigen stimulation. lnterleukin-4(IL-4) and IL-13 secreted by Th2 cells act on macrophages and acti-vate them into M2 macrophages via "alternative activation". When lung tissue is continuously stimulated by the antigen, the alveolar and interstitial macrophages are activated by IL-4 and IL-13 secreted by Th2 cells to form M2 type alveolar macrophages, thereby participating in pulmonary fibrosis (PF). The process shows that M2 alveolar macrophages play an important role in PF. In this review, we investigated the role of cytokine IL-4 and IL-13 in PF, the anti-inflammatory and profibrotic effects of M2 alveolar macrophages, the role of IL-4 and IL-13 receptors in the treatment of PF and the dual role of M2 alveolar macrophages activated by IL-4 and IL-13 in PF. Hoping to spark novel ideas for the study of anti-PF drugs.