Research on Quality Control Methods of Panax ginseng, Panax quinquefolius, Panax notoginseng and Related Proprietary Chinese / 中国药学杂志

ABSTRACT

OBJECTIVE： To explore Q-markers of Panax ginseng, Panax quinquefolius, Panax notoginseng and establish the content determination method based on the concept and research model of Q-marker. METHODS： The material basis and biosynthesis pathway of Panax ginseng, Panax quinquefolius, Panax notoginseng were analyzed. The main components of three medicinal materials were determined by liquid chromatography-mass spectrometry, and methods for determination of Q-markers in Panax ginseng, Panax quinquefolius, Panax notoginseng herbs and proprietary Chinese medicine were established. RESULTS： The Q-markers of Panax ginseng, Panax quinquefolius, and Panax notoginseng were their specific constituents, including ginsenosides Rf, pseudo ginsenoside F11, notoginseng saponins R1, and the ratio feature of the common constituents, including ginsenosides Rg1, ginsenosides Re, and ginsenosides Rb1. METHODS for determination of Q-markers in Panax ginseng, Panax quinquefolius, Panax notoginseng herbs and proprietary Chinese medicine were established by ultra-high performance liquid chromatography (UPLC) and ultra-high performance liquid chromatography-electrospray ionization quadruple mass spectrometry (UPLC/MS/MS). CONCLUSION： The Q-markers which were selected are scientific and reasonable, also can reflect the characteristics of the three medicinal materials. The established methods would improved the quality control level of Panax ginseng, Panax quinquefolius, Panax notoginseng and related proprietary Chinese medicine.