Increased Nasal Interleukin-33 in the Infants with Acute Respiratory Syncytial Virus Bronchiolitis / 소아알레르기및호흡기학회지
Pediatric Allergy and Respiratory Disease
; : 383-389, 2012.
Article
en Ko
| WPRIM
| ID: wpr-85797
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: Interleukin (IL)-33, a member of the IL-1 cytokine family, is considered to be important for innate-type mucosal immunity of the lung and also has been suggested to induce Th2-type immune responses. We aimed to investigate if IL-33 is involved in airway inflammation due to respiratory syncytial virus (RSV) infection in young children. METHODS: Thirty-eight infants ( or =2 of the following clinical findings: hypoxemia (7 days of hospital stay. The levels of IL-33 and the IL-33 receptor (sST2) were measured using enzyme-linked immunosorbent assay in nasal secretion samples collected from the patients on admission and compared with 20 age-matched controls. We also investigated the levels of IL-33 and sST2 in relation to the atopic status and symptom severity of the patients. RESULTS: Nasal IL-33 levels in the patients with acute RSV bronchiolitis were significantly increased (P<0.05), but sST2 showed no difference compared to the controls. Neither IL-33 nor sST2 showed significant difference in relation to the atopic status or severity of symptoms. CONCLUSION: Our study showed significantly increased IL-33 in the nasal secretions of the young infants admitted with acute RSV bronchiolitis and suggests that IL-33 is involved in the pathogenesis of RSV-induced airway inflammation.
Palabras clave
Texto completo:
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Índice:
WPRIM
Asunto principal:
Oxígeno
/
Respiración
/
Virus Sincitiales Respiratorios
/
Piel
/
Inmunoglobulina E
/
Inmunoglobulinas
/
Ensayo de Inmunoadsorción Enzimática
/
Bronquiolitis
/
Interleucinas
/
Interleucina-1
Límite:
Humans
/
Infant
Idioma:
Ko
Revista:
Pediatric Allergy and Respiratory Disease
Año:
2012
Tipo del documento:
Article