Chemical constituents from rhizome of phlomis umbrosa / 中国药学杂志

ABSTRACT

OBJECTIVE: To study the chemical constituents from the rhizome of Phlomis umbrosa. METHODS: Chemical constituents were isolated by repeated column chromatographies(Toyopearl HW-40C and preparative HPLC). The structures were elucidated on the basis of spectral data analysis. RESULTS: Seventeen compounds were isolated from the 95% ethanol aqueous extract of P. umbrosa and the structures were identified as lamalbid (1), phloyoside (2), phloyoside Ⅱ(3), 6-O-acetylshanzhiside methyl ester(4), shanzhiside methyl ester (5), 8-acetylshanzhiside methyl ester(6), sesamoside(7), 5,9-epi-7,8-didehydropenstemoside(8), verbascoside(9), isoverbascoside(10), forsythoside B(11), alyssonoside(12), echinacoside(13), (17S)-2α,3α,18β,23,24-pentahydroxy-19(18→17)-abeo-28-norolean-12-en-21-one(14),(17S)-19(18→17)-abeo-12-en-28-norolean-2α,3α,18β,19,23,24-hexaol (15), friedelin(16), and daidzein(17). CONCLUSION: All compounds are isolated from this plant for the first time, compounds 1, 8, 16-17 are isolated from genus Phlomis for the first time.