Five Cases of Bisphosphonate Therapy on Children with McCune-Albright Syndrome and Literature Review / 中国药学杂志

ABSTRACT

OBJECTIVE: To provide references for clinical rational drug use through five empirical analysis of zoledronate′s application on children with McCune-Albright syndrome.METHODS: The clinical data of five children with McCune-Albright syndrome were analyzed and summarized. Literature review was conducted to analyze long-term out come of bisphosphonate therapy and factors influencing outcome of bisphosphonate therapy in fibrous dysplasia. RESULTS:Bisphosphonate therapy achieved certain effects, and there were no serious adverse events occurred. CONCLUSION: Bisphosphonate therapy can be used on children with McCune-Albright syndrome,the prognostic factor that influencing outcome of bisphosphonate therapy is the extent of skeletal involvement.