Simultaneous Determination of Four Lactones Ingredients Content in Yinxingye Tablets by Quantitative Analysis of Multi-Components by Single-Marker / 中国药学杂志

ABSTRACT

OBJECTIVE To determine simultaneously four lactones ingredients content in Yinxingye tablets by quantitative analysis of multi-components by single-marker (QAMS), and to verify the application value of this method in the quality control of Yinxingye tablets. METHODS With Ginkgo esters as the indexes,the relative correction factor(RCFs) between bilobalide and ginkgolides A,B,C were established. The content of bilobalide in Yinxingye tablets were determined by external standard method,the content of ginkgolides A,B,C in Yinxingye tablets was calculated by the relative correction factor. The external standard method and QAMS determined contents of 4 lactones, Rationality, feasibility and repeatability of the QAMS method were verified by comparing the results obtained from two different methods. RESULTS There was no significant differences between the calculated value and estimated value on QAMS and external standard method of the 5 batches of Yinxingye tablets,the results showed that the RCF was authentic. CONCLUSION The established correction factor is good repeatability,and could be used for quantitative analysis and quality evaluation of multiple components in Yinxingye tablets.