Recent Advances in Neuroprotective Mechanisms of Astaxanthin in Acute Brain Injury and Neurodegenerative Disease / 中国药学杂志

ABSTRACT

Astaxanthin( 3, 3 '-dihydroxy-β, β'-carotene-4, 4 '-dione, ATX), a xanthophyll carotenoid produced naturally and synthetically, is a red-orange carotenoid with unique cell membrane actions and diverse biological activities. The beneficial effects of astaxanthin are linked to its oxidative, anti-inflammatory, and anti-apoptotic characteristics. More importantly, there is evidence demonstrating that astaxanthin confers neuroprotective effects in experimental models of neurological diseases. In this review, we will provides up-todate information on the neuroprotective properties of astaxanthin in mitigating neuropathy in acute brain injury and neurodegenerative disease, and discuss its mechanistic details relating preclinical studies.