Structure and Gene Polymorphism Affect the Metabolism of Statins / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 6-9, 2018.
Artículo
en Chino
| WPRIM
| ID: wpr-858459
ABSTRACT
Statins are the main drugs for high cholesterol. The different chemical structures affect the metabolize way of statins. Different chemical structures of statins lead to differences in hydrophobicity and affect the degree of membrane transport and tissue affinity. The differences in hydrophobicity may influence the absorption of statins and the distribution in important organs. The metabolism of statins in vivo is mainly related to drug metabolizing enzymes. Gene polymorphism affects the activity and capacity of enzymes and may influence the lipid-lowering effect of statins. This paper reviews the transshipment and metabolic characteristics of statins. We summarize the gene polymorphism on the effect of drug metabolism and conduct the clinical prescription.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Pharmaceutical Journal
Año:
2018
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS