Preparation of Hypromellose Hollow Capsules / 中国药学杂志

ABSTRACT

OBJECTIVE: To prepare hypromellose(HPMC) hollow capsules by hypromellose as raw material, adding gel, coagulant and plasticizer. METHODS: Using hypromellose and k-carrageenan as main material, the HPMC hollow capsules were prepared by sol preparing, glue keeping, sheet stamping, drying, cutting and superposition sequentially. Glue viscosity, properties, yield and water content of capsule were used as indicators to optimize formula and preparation parameters by single factor experiments and orthogonal experiments. RESULTS: The most appropriate formula and preparation conditions were as follows HPMC (E5) 16.5%, k-carrageenan 0.9%, and sol dissolving time 30 min under 90℃, glue keeping temperature 45-50℃, sheet stamping 45-50℃, drying 2-2.5 hr in condition of 35℃. CONCLUSION: The key performance indicators like apparent shape, disintegration time etc of HPMC hollow capsules meet the requirements of the national standard. The preparation is suitable for industrial production.