Preparation and Properties of Rifampicin-loaded Pluronic L61-PBSu Nanoparticles / 中国药学杂志

ABSTRACT

OBJECTIVE: To study the preparation of pluronic-modified biodegradable poly(butylene succinate) (PBSu) nanoparticles (NPs) and evaluate the release kinetics of the drug-loaded PBSu NPs and the cytotoxicity of the NPs, so as to provide a new platform for the application of biodegradable PBSu in drug delivery. METHODS: Pluronic L61-modified PBSu NPs were prepared by emulsification method, and the morphology of the NPs was observed by transmission electron microscopy. The in vitro release kinetics of the rifampicin-loaded L61-PBSu NPs at 37 ℃ was studied. The cytotoxicity of the L61-PBSu NPs against human ovarian cancer cells (OVCAR-3) was evaluated by MTT assay. RESULTS: The drug-loaded NPs had a unimodal distribution with an average size of (140±7) nm. The drug encapsulation efficiency attained 64.98%. The release time reached 27 h when the cumulative release percentage was 90%. The release kinetics followed non-Fickian mechanism. The NPs demonstrated very low cytotoxicity against OVCAR-3 cancer cells. Modification by L61 improved biocompatibility. CONCLUSION: The Pluronic-modified PBSu NPs are easy to prepare, biocompatible, and show great promise as a new passive targeting platform for controlled release of insoluble drugs.