Influence of Tripterygium Glucoside Tablet on the Pharmacokinetics of Atorvastatin in Rats / 中国药学杂志

ABSTRACT

OBJECTIVE: To investigate the influence of tripterygium glucoside tablet on the pharmacokinetics of atorvastatin in rats. METHODS: Twelve rats were equally randomized to two groups (six rats in each group), including the atorvastatin-only group (A) and the tripterygium glucoside tablet and atorvastatin group (B). Animals in group A were administered according the oral dose of 2 mg·kg-1; and animals in group B were administered at an oral dose of atorvastatin (2 mg·kg-1)and tripterygium glucoside tablet (2 mg·kg-1). Blood samples were collected into a heparinized tube via the oculi chorioideae vein at different time points after drug administration, and the plasma concentration of atorvastatin were determined using HPLC-UV. Finally, the pharmacokinetic profiles of atorvastatin were calculated and compared. RESULTS: Compared with the atorvastatin-only group(A), the pharmacokinetic parameters of the tripterygium glucoside tablet and atorvastatin group(B) have changed greatly. ρmax of atorvastatin increased from (4.77±0.64) to (7.79±0.61) mg·L-1, and AUC0-t increased from (12.82± 3.50) to (27.39±5.76) mg·h·L-1, at the same time, tmax was extended from (0.25±0.03) to (0.52±0.07) h, t1/2 was prolonged from (2.39±0.19) to (5.09±1.35) h, MRT was extended from (2.93±0.23) to (4.36±0.44)h. It indicates that the metabolism of atorvastatin may be suppressed. CONCLUSION: The RESULTS indicate that tripterygium glucoside tablet could influence the pharmacokinetics of atorvastatin when atorvastatin and tripterygium glucoside tablet are used concomitantly. This study could be used for clinical medication guidance of tripterygium glucoside tablet and atorvastatin to avoid the occurrence of adverse reactions.