Brief Analysis of Aspirin Resistance and Its Implications / 中国药学杂志

ABSTRACT

OBJECTIVE: Individuals taking aspirin but who fail to appropriately respond to the medication may remain at higher risk of thrombotic events. To provide reference for rational use of aspirin and reduce the risk of adverse reactions, clinical pharmacists need to comprehend the status of aspirin resistance. METHODS: We have reviewed, analyzed, and summarized domestic and foreign literatures published in the last five years that are related to aspirin resistance. RESULTS: The term "aspirin resistance" still has no standard accepted definition in the literature. Researchers focus on molecular insights into the mechanisms of aspirin resistance. The absolute as well as relative contributions of various factors to the phenomenon of aspirin resistance are the subject of current research. There are diverse platelet function testing methods and each has its strengths and weaknesses, which will greatly increase the difficulty of selection. CONCLUSION: In order to have a comprehensive assessment and interpretation of laboratory data, clinical pharmacists need to understand the research progress of aspirin resistance, which will promote personalized medication of aspirin.