Lignan Constituents of Patrinia villosa (Thunb.) Juss / 中国药学杂志

ABSTRACT

OBJECTIVE: To study the chemical constituents of Patrinia villosa (Thunb.) Juss. METHODS: The compounds were isolated by a combination of various chromatographic techniques including column chromatography over macroporous resin, Sephadex LH-20, and reversed-phase HPLC. Their structures were elucidated by physiochemical property and spectral analysis. RESULTS: Eleven compounds were isolated and identified as(7R, 8S)-3, 3', 5-trimethoxy-4', 7-epoxy-8, 5'-neolignan-4, 9, 9'-triol-9-O-β-D-glucopyranoside(1), massonianoside D(2), (7R, 8S)-dihydroxydehydrodiconiferyl alcohol-4-O-β-D-glucopyranoside(3), (7S, 8R)-dihydroxydehydrodiconiferyl alcohol-4-O-β-D-glucopyranoside(4), 7R, 8S-glochidioboside(5), lariciresinol-4-O-β-D-glucopyranoside(6), lariciresinol-9-O-β-D-glucopyranoside(7), lariciresinol-4'-O-β-D-glucopyranoside(8), tortoside B(9), tanegool(10), and tanegool-7'-methyl ether(11). CONCLUSION: All compounds are isolated from Patrinia genus for the first time.