Preparation and Quality Analysis of Osthole Microcapsules-Temperature-sensitive Gel / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1044-1048, 2017.
Artículo
en Chino
| WPRIM
| ID: wpr-858675
ABSTRACT
OBJECTIVE:
To optimize the preparation process of osthole microcapsules-temperature-sensitive gel and set up its quality standard.METHODS:
Using gelling temperature as the indicator, P407, P188 and the concentration of propylene glycol were investigated by single factor test, and orthogonal experiment was conducted to optimize the preparation process of osthole microcapsules-temperature-sensitive gel. Osthole content was determined by HPLC. The quality standard of osthole microcapsules-temperature-sensitive gel was established.RESULTS:
The optimal formulation of osthole microcapsules-temperature-sensitive gel was as followsP407-P188-propylene glycol=18%∶1%∶15%. Osthole contentin the osthole microcapsules-temperature-sensitive gel should not be less than 31.77 μg·mL-1, and the gelling temperature should be 36-37℃.CONCLUSION:
Osthole microcapsules-temperature-sensitive gel prepared in this study has reasonable composition, simple preparation process, and stable quality standards, indicating a hopeful application prospect.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Pharmaceutical Journal
Año:
2017
Tipo del documento:
Artículo
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