Preparation and Properties of Sulfadiazine Solid Dispersion / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 750-754, 2017.
Artículo
en Chino
| WPRIM
| ID: wpr-858723
ABSTRACT
OBJECTIVE:
To prepare sulfadiazine solid dispersion, determine its solubility and dissolution in vitro, and investigate its physical properties.METHODS:
Using in vitro dissolution as an index, single factor test and orthogonal design were used to optimize the preparation process of sulfadiazine solid dispersion. The existing state of sulfadiazine was identified by DSC, IR spectroscopy, and powder X-ray diffraction.RESULTS:
The solubility and dissolution rate of sulfadiazine solid dispersion prepared by the optimized preparing process were increased by 17 times and 3 times respectively than crude sulfadiazine. Sulfadiazine existed in an amorphous state as shown by phase identification.CONCLUSION:
The solid dispersion prepared by the solvent-molten method with PEG4000 as the carrier can significantly improve the solubility and the dissolution rate of sulfadiazine.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio pronóstico
Idioma:
Chino
Revista:
Chinese Pharmaceutical Journal
Año:
2017
Tipo del documento:
Artículo
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