Research Progress of Bile Acid Transporters / 中国药学杂志

ABSTRACT

Bile acids participated in regulation of many physiological functions in the human body. Transporters in liver and intestinal play an important role in maintaining the enterohepatic circulation and bile acid homeostasis. With the rapid development of molecular biology in recent years, there has been great progress toward cloning and identifying the individual bile acid transporters and explaining their complex regulation. Bile acid transporters were regulated by various factors including bile acids, nuclear receptors, transcription factors, hormones, etc., which influence their protein expression, cell location and transport activities. This article reviews the research progress of bile acid transporters for the purpose of providing references for the mechanism research of bile acid transporter related disorders and drug development.