Minocycline inhibits MPTP-induced the behavior damage in C57BL/6 mice / 中国药学杂志

ABSTRACT

OBJECTIVE: To investigate the effect of minocycline on the behavior damage induced by 1-methyM-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in C57BL/6 mice. METHODS: The PD models were formed with intraperitoneal injections of MPTP in C57BL/6 mice. Forty mice were randomly divided into 4 groups; control group, MPTP group, MPTP+Mino group and Mino group (10 for each group). The levels of midbrain DA, DOPAC and HVA were measured by HPLC after behavior tests (swimming test, pole test and locomotor activity test) were performed. RESULTS: Swimming scores, climbing score and locomotor activity of MPTP+Mino group were significantly higher than the MPTP group (P<0.01). And the content of midbrain DA, DOPAC and HVA of MPTP+Mino group was significantly higher than the MPTP group (P<0.01). CONCLUSION: Minocycline inhibits MPTP-induced damage of motor function in mice, the mechanism may be work via inhibiting MPTP-induced mice dopamine neuron damage.