Research progress of in vitro release evaluation methods for nano preparation / 中国药学杂志

ABSTRACT

In vitro release is an important index to evaluate the quality of nano preparation, but there is no pharmacopoeia standard of in vitro release evaluation METHODS of nano preparation exists at present, it seriously restricts the safety improvement of nano preparation and the progress of its product development. The main in vitro release evaluation METHODS of nano preparation at present are sample and separate method, flow through cell method, dialysis method, franz diffusion cell method, combination METHODS, and the new METHODS of electrochemical method, nonelectrochemical method and microdialysis method. With the aim to optimize the improvement and development of in vitro release evaluation METHODS of nano preparation, this paper combined with the special properties of nano preparation and provided mainly the research status of in vitro release evaluation METHODS of nano preparation in recent years and their strengths and shortcomings.