Synthesis and antitumor activities of 8-aminobenzofuran3, 2-d pyrimidine derivatives / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 690-693, 2016.
Artículo
en Chino
| WPRIM
| ID: wpr-859117
ABSTRACT
OBJECTIVE:
To synthesize the derivatives of 8-amino benzofuran[3, 2-d] pyrimidine and study their anticancer activiies.METHODS:
The target compounds were synthesized through a series of reactions, and their anticancer activities in vitro were evaluated against COLO205, MCF-7 and K562 cell lines by MTT as assay.RESULTS:
Nine title compounds were synthesized and confirmed by EI-MS, 1H-NMR and 13C-NMR. Compounds 2, 3d and 5c had good inhibition effect against COLO205, MCF-7 and K562 cells. The inhibition rates of compound 5c against COLO205, MCF-7 and K562 cells were 99.58%, 78.75% and 98.68% respectively at 10-4 mol · L-1.CONCLUSION:
The anticancer activity of benzofuran[3, 2-d] pyrimidine derivatives is worthy of further study.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Pharmaceutical Journal
Año:
2016
Tipo del documento:
Artículo
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