Preparation of garcinia glycoside bilayer tablets and its in vitro release / 中国药学杂志

ABSTRACT

OBJECTIVE: To optimize the prescription and preparation process of garcinia glycoside bilayer tablets and study the drug release mechanism in vitro. METHODS: Solid dispersions were prepared by using water soluble carrier material polyethylene glycol (PEG) and then used to prepare the rapid release layer. Hydroxypropylmethyl cellulose (HPMC) was used as main sustained release material to prepare the sustained release layer. The formulations of rapid release layer and sustained release layer were optimized by using univariate analyses. DDslover software was used to fitting drug release curve. RESULTS: The content of the garcinia glycoside in the bilayer tablets was 98.5% and its release rate was consistent with the rule of release in vitro. The release behavior of the sustained release layer in vitro followed Higuchi equation (r=0.998 3). The main mechanism of drug release was the synergistic action of diffusion and dissolution. CONCLUSION: Garcinia glycoside bilayer tablets prepared by this method can achieve the goal of both rapid-acting and long-acting.