Preparation and modification of capsaicin solid lipid nanoparticles / 中国药学杂志

ABSTRACT

OBJECTIVE: To prepare capsaicin-solid lipid nanoparticles (CAP-SLNs) and study their physical and chemical properties. Then, the CAP-SLNs were modified with chitosan (CTS) and the pharmacokinetics across colon of rats was studied in vivo. METHODS: CAP-SLNs were prepared by emulsion-solvent evaporation method. The mean size, encapsulation efficiency and drug loading of the nanoparticles were investigated. RESULTS: The average diameter of CAP-SLNs was (118.89 ±25.0) nm, the encapsulation efficiency was (38.56 ±2.6)%, and the drug-loading was (6.17 ±0.21)%. After colon-specific delivery in rats, the AUC0.360 min(243. 63 ±61.46) mg · min · L-1 and ρmax(1.23 ±0.18) mg · L-1 of CTS-CAP-SLNs were 1.81-fold and 1.95-fold higher than CAP. CONCLUSION: It is simple and feasible to prepare CAP-SLNs by emulsion-solvent evaporation method. The pharmacokinetic parameters in rats are improved remarkably compared with CAP.