Mechanisms of resistance to PBK-Akt-mTOR signaling pathway inhibitors / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 253-258, 2016.
Artículo
en Chino
| WPRIM
| ID: wpr-859199
ABSTRACT
The resistance to PBK-Akt-mTOR pathway inhibitors has close relationship to the negative feedback of its context-dependent signal pathways. According to our current understanding, the resistant mechanisms could be divided into the following basic conditions related to FOXO and hormone receptor, MYC-dependence, β-catenin-dependence, JAK/STAT pathway-dependence, MAPK pathway-dependence and related to AXL. The emergence of drug resistance to PBK-Akt-mTOR pathway inhibitors has greatly limited their curative effect. The reported resistance mechanisms to PBK-Akt-mTOR pathway inhibitors to search for potential strategies for overcoming resistance by drug combination were summarized.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Pharmaceutical Journal
Año:
2016
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS