Chemical constituents from Bletilla striata and their anti-tumor activities / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 101-104, 2016.
Artículo
en Chino
| WPRIM
| ID: wpr-859235
ABSTRACT
OBJECTIVE:
To investigate the chemical constituents from Bletilla striata (Thunb.) Reichb.f and study their antitumor activities and effect on progression of cell cycle.METHODS:
The compounds were isolated by various chromatographic methods including silica gel, ODS, Sephadex LH-20, and so on. Their structures were identified by extensive analysis of spectroscopic data. The antiproliferative effects of the compounds were evaluated using MTT test, and compound 1 was tested for the effect on the cell cycle of A549 cells.RESULTS:
Five compounds were isolated from Bletilla striata and identified as 3β-hydroxyoleane-12-en-28-oic acid 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside(1), 2-hydroxysuccinic acid(2), 4-hydroxybenzylamine(3), palmitic acid(4), and 4-hydroxybenzoic acid(5). Compound 1 showed antiproliferative activity against the cancer cells and could induce G0/G1 phase arrest effectively after 24 h treatment.CONCLUSION:
Compounds 1-4 are isolated from Bletilla striata for the first time. Compound 1 shows potent inhibitory effect and might produce their action through inducing cell cycle arrest.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Pharmaceutical Journal
Año:
2016
Tipo del documento:
Artículo
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