Systematic review of effectiveness and safety of nedaplatin and cisplatininthe in treatment of advanced nasopharyngeal carcinoma / 中国药学杂志

ABSTRACT

OBJECTIVE: To evaluate the effectiveness and safety of nedaplatin versus cisplatin in the treatment of local advanced nasopharyngeal carcinoma. METHODS: Such databases as Cochrane Library, Pubmed, Embase, CNKI, VIP, WanFang data and CBM were searched from the date of their establishment to April 2015 to collect the randomized controlled trials on chemotherapy containing nedaplatin versus cisplatin for local advanced nasopharyngeal carcinoma. According to the inclusion and exclusion criteria, two reviewers independently screened literature, extracted data and assessed the quality. The Meta-analysis was carried out by Revman 5.3 software. RESULTS: A total of nine RCTs involving 1032 patients were included. The results of Meta-analysis suggested that, compared with cisplatin-containing chemotherapy, nedaplatin-containing chemotherapy had comparable short-term effects and similar incidences of leukopenia, liver function impairment and neurovirulence, and lower incidences of nausea and vomiting without statistically significant difference. Meanwhile nedaplatin-containing chemotherapy could significantly reduce the risk of anemia (RR=0.81, 95% CI 0.70 to 0.94, P=0.004) and renal function impairment (RR=0.35, 95% CI 0.19 to 0.67, P=0.001), but it was associated with higher risk of thrombocytopenia (RR=1.35, 95% CI 1.17 to 1.57, P<0.0001). CONCLUSION: Nedaplatin chemotherapy can be an alternative regimen to cisplatin chemotherapy for advanced nasopharyngeal carcinoma patients who are unable to tolerate the side effects of cisplatin.