Research progress of the role of autophagy in alzheimer's disease and drug intervention / 中国药学杂志

ABSTRACT

Autophagy is a specific phenomenon of life which is widespread in eukaryotic cells and is also a main cell metabolic pathway of long-lived proteins and cytoplasmic organelles degradation. Alzheimer's disease (AD), also known as senile dementia, is a degenerative disease of the central nervous system. There are a large number of autophagy vesicles in neurocytes in the AD patients or transgenic mice, which indicating that autophagy may participate in the cleaning and deposition of abnormal protein, neuronal survival, and injury at different stages in the development of AD. Recognizing the role of autophagy in AD has great significance for further understanding the pathogenesis of AD and slowing the progress of AD through regulating autophagy by drug intervention. This review has researched the articles at home and abroad in recent years to summarize the progress of the role of autophagy in AD and analysis the drug intervention in AD based on the autophagy to provide a theoretical foundation for the treatment strategies of AD.