Preparation of esomeprazole magnesium enteric-coated capsules / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 789-792, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-859467
ABSTRACT
OBJECTIVE:
To prepare and evaluate esomeprazole magnesium enteric-coated capsules which is compacted by multiple-unit pellet system (MUPS).METHODS:
The esomeprazole magnesium enteric-coated pellets were prepared by fluid bed coating technology, and the effects of isolation layer, amont of core, and thickness of enteric-coated film on the quality of the product were e-valuated.RESULTS:
The prepared esomeprazole magnesium enteric-coated capsules showed good release behavior in artificial gastric fluid. The dissolution in artificial intestinal fluid was rapid and complete.CONCLUSION:
The established process of preparing esomeprazole magnesium enteric-coated pellets is feasible and reproducible, and the product has similar quality with the original preparation. It is expected to be used in the industrial production.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Pharmaceutical Journal
Año:
2015
Tipo del documento:
Artículo
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