Investigation on determination of the content of polysorbate 80 in traditional Chinese medicine injections / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 990-993, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-859712
ABSTRACT
OBJECTIVE:
To point out the problems of the SEC-ELSD method for determination of polysorbate 80 in traditional Chinese medicine injections, and discuss the method.METHODS:
The retention behaviors of eight types of chemical compositions in polysorbate 80 in size exclusion chromatography were studied according to the chromatographic conditions of SEC-ELSD method.RESULTS:
Not all of the chemical compositions had same chromatographic retention time, some of them showed no chromatographic peaks in the chromatographic conditions of SEC-ELSD method.CONCLUSION:
In order to ensure the rational use of SEC-ELSD method, researchers must be concerned about the state of the surfactant molecules in the mobile phase and the interaction between surfactant molecules with the stationary phase. A new standard of polysorbate 80 must be implemented, the core of which is controlling the chemical compositions.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Pharmaceutical Journal
Año:
2014
Tipo del documento:
Artículo
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