Pharmacokinetics in rabbits of oxybutynin hydrochloride ethosomal gel / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 588-591, 2014.
Article
en Zh
| WPRIM
| ID: wpr-859783
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WPRO
ABSTRACT
OBJECTIVE: In vivo study on the oxybutynin hydrochloride (OXB) ethosomal gel in rabbits was carried out to obtain pharmacokinetic parameters in comparison to contrast gel. METHODS: After transdermal administration in rabbits of the OXB ethosomal gel and contrast gel respectively, OXB in the plasma was determined by HPLC-MS, the pharmacokinetic parameters were calculated with DAS 2.1.1. RESULTS: Dose of OXB for 20 mg in the ethosomal gel and for 50 mg in contrast gel transdermal delivery, the AUC0→48 of ethosomal gel and contrast gel were 597.63, 518.40 ng · h · mL-1, ρmax were 27.91, 29.81 ng · mL-1, and tmax were 6.67, 4.67 h respectively. A relative bioavailability of OXB ethosomal gel was 288.4% compared with contrast gel. CONCLUSION: In vivo experiments indicate that the OXB ethosomal gel not only reduce the drug dosage, but also show good bioavailability in rabbits.
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WPRIM
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Zh
Revista:
Chinese Pharmaceutical Journal
Año:
2014
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Article