Pharmacokinetics studies of ginsenoside Rb1 in rats / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 221-226, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-859855
ABSTRACT
OBJECTIVE:
To develop a highly snsitive and specific LC-MS/MS method to explore the pharmacokinetic propeties of ginsenoside Rb1.METHODS:
Ginsenoside Rb1 dissolved in normal saline was administered in a dose of 100 mg·kg-1 via gastric in fusion and 10 mg·kg-1 by intravenous injection in rats. Plasma was collected from fundus oculi venous plexus and ginsenoside Rb1 was analyzed by a validated LC-MS/MS method in plasma after intravenous and oral administration. The pharmacokinetic parameters were evaluated by software PKSolver V2.0.RESULTS:
The main pharmacokinetic parameters of ginsenoside Rb1 after oral administration of 100 mg·kg-1 dosage were as follows ρmax (2.01 ± 0.93) μg·mL-1, tmax (7.20 ± 5.49) h, t1/2 (25.91 ± 15.84) h, AUC0~96h (88.47 ± 58.99) μg·h·mL-1. The main pharmacokinetic parameters of ginsenoside Rb1 after intravenous administration of 10 mg ·kg-1 dosage were as follows ρmax (194.81 ± 28.84) μg·mL-1, t1/2α (0.18 ± 0.05) h, t1/2β (14.66 ± 4.19) h, AUC0~96h (1671.16 ± 388.91) μg·h·mL-1.CONCLUSION:
The ginsenoside Rb1 of orally administered was 0.62%, shows poor absolute bioavailability, and intravenous injection directly distribute into the blood vessels, can be the priority.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Pharmaceutical Journal
Año:
2014
Tipo del documento:
Artículo
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