Protective effect of methylamine irisolidone on cardiac function in rats with acute myocardial infarction / 中国药学杂志

ABSTRACT

OBJECTIVE: To observe the effect of a new compound methylamine irisolidone on cardiac function in rats with experiment myocardial infarction. METHODS: The male Wistar rats were randomly divided into 6 groups control group, ischemia model group, methylamine irisolidone preconditioning group, pretreated with different dosages of methylamine irisolidone (200,100,50 mg · kg-1, respectively) and 200 mg · kg-1 puerain(positive control). Coronary artery ligation was used to induce the acute myocardial ischemia model. After 30 d administration of methylamine irisolidone, the heart function parameters,including heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP), maximal velocity of increase and decrease of left ventriclar pressure (dp/dtmax), were analyzed and myocardial histology was analyzed by hematoxylin-eosin staining. RESULTS: Compared with model group, methylamine irisolidone could improve the heart function of rats in AMI injury, increased the systolic pressure and diastolic pressure, decreased the heart rate(P < 0.01). The myocardial ultrastructure injury was alleviate. CONCLUSION: Methylamine irisolidone had cardioprotective effects on acute myocardial ischemia. The mechanism may be related to slow down heart rate, prolong diastolic, so that an increase in the endocardial blood supply.