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Development of software for individualized dosage regimen of valproic acid and carbamazepine / 中国药学杂志
Chinese Pharmaceutical Journal ; (24): 163-166, 2014.
Artículo en Chino | WPRIM | ID: wpr-859879
ABSTRACT

OBJECTIVE:

To develop software for individualized dosage regimen of valproic acid and carbamazepine according to population pharmacokinetics and Bayesian estimation method.

METHODS:

Based on the prior population pharmacokinetic (PPK) information, Microsoft Excel 2010 was employed as the input-output interface to run the PPK program, Nonlinear Mixed Effect Modeling (NONMEM), to estimate the PK parameters and design the regimen.

RESULTS:

The software fulfills the functions of patient information management, initial dosage design, dosage calculation by maximum a posterior Bayesian estimation (MAPB) and compliance assessment.

CONCLUSION:

The established software provides a powerful tool in the clinical settings to facilitate the individualized therapy for the epilepsy patients.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Pharmaceutical Journal Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Pharmaceutical Journal Año: 2014 Tipo del documento: Artículo