Development of software for individualized dosage regimen of valproic acid and carbamazepine / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 163-166, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-859879
ABSTRACT
OBJECTIVE:
To develop software for individualized dosage regimen of valproic acid and carbamazepine according to population pharmacokinetics and Bayesian estimation method.METHODS:
Based on the prior population pharmacokinetic (PPK) information, Microsoft Excel 2010 was employed as the input-output interface to run the PPK program, Nonlinear Mixed Effect Modeling (NONMEM), to estimate the PK parameters and design the regimen.RESULTS:
The software fulfills the functions of patient information management, initial dosage design, dosage calculation by maximum a posterior Bayesian estimation (MAPB) and compliance assessment.CONCLUSION:
The established software provides a powerful tool in the clinical settings to facilitate the individualized therapy for the epilepsy patients.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Pharmaceutical Journal
Año:
2014
Tipo del documento:
Artículo
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